n. 1 bone at a fingerjoint, esp. that connecting the finger to the hand. 2 a knee. or anklejoint of a quadruped. b this as a joint of meat, esp. of bacon or pork. v. (ling) strike, press, or rub with the knuckles. knuckle down (often foil. by w) 1 apply oneself seriously (to a task etc.). 2 (also knuckle under) give in; submit. [Low German or Dutch diminutive of knoke bone]